The nocebo effect: Implications for biosimilar medicines

The nocebo effect is the opposite of the placebo effect, whereby a patient receiving treatment may experience a negative outcome that is unrelated to the pharmacological actions of the treatment.1-3

Any treatment or therapy area can be susceptible to the nocebo effect, and there are simple and effective communication strategies that clinicians can adopt with patients to mitigate its occurrence.4-11

The nocebo effect: Implications for biosimilar medicines

References

1. Weissenfeld J, et al. Die Pharmazie – An International Journal of Pharmaceutical Sciences 2010;65(7):451–456;
2. Faasse K, et al. Front Psychiatry 2019;10:396;
3. D’amico F, et al. Digest Liver Dis 2020;52(2):138–142;
4. Colloca L and Miller F. Psychosom Med 2011;73(7):598–603;
5. Colloca L, et al. Front Pharmacology 2019;10:1372;
6. Planes S, et al. Pharmacol Res Perspect 2016;4(2):e00208;
7. Lembo AJ. Gastroenterol Hepatol 2020;16(7):374;
8. Mondaini N, et al. J Sex Med 2007;4(6):1708–1712;
9. Varelmann D, et al. Anesth Analg 2010;110(3):868–870;
10. Nabi H, et al. RMD Open 2022;8(2):e002560;
11. Blasini M, et al. Int Rev Neurobiol 2018;139:211–231;
12. Pouillon L, et al. Expert Rev Clin Immunol 2018;14(9):739–749;
13. Thiel P, et al. Reproduction and Fertility 2021;2(4):C45–48.

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