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Pregnancy planning may impact maternal and neonatal outcomes in people with myasthenia gravis

Myasthenia Gravis (MG) is an acquired autoimmune condition commonly diagnosed in young people of reproductive age resulting in neuromuscular junction dysfunction. The course of MG during pregnancy and its impact on maternal and neonatal outcomes is vary in the literature.

December 2023

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Refocusing generalized myasthenia gravis: Patient burden, disease profiles, and the role of evolving therapy

Generalized myasthenia gravis (gMG) continues to present significant challenges for clinical management due to an unpredictable disease course, frequent disease fluctuations, and varying response to therapy. The recent availability of new pharmacologic therapies presents a valuable opportunity to reevaluate how this disease is classified, assessed, and managed and identify new ways to improve the clinical care of patients with gMG.

December 2023

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Diagnosis and evaluation of elderly-onset myasthenia gravis: A case report

Patients with elderly-onset myasthenia gravis can have a good prognosis with appropriate diagnosis and response, although it is difficult to differentiate between exacerbations of myasthenia gravis in elderly patients and age-related changes. Therefore, it is important for physicians to understand the clinical characteristics and safe assessment methods for patients with elderly-onset myasthenia gravis.

January 2024

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Facial-onset sensory and motor neuronopathy with myasthenia gravis: A case report

Facial-onset sensory and motor neuronopathy (FOSMN) is a greatly rare disease, so far, autopsy evidence that is associated with neurodegenerative. Myasthenia gravis (MG) is an antibody-mediated and complement-involved acquired autoimmune disorder of the post-synaptic neuromuscular junction. There have been few reports about if there is related between the 2. In this study, we present the case of a man who was diagnosed as FOSMN with MG in continuity.

November 2023

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Correlation of fatigue on walking ability in myasthenia gravis patients: a cross-sectional study

Myasthenia gravis (MG) is a neuromuscular junction autoimmune disease characterised of intermittent muscle weakness that increases with activity and recovers with rest.

January 2024

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Effect of Light-Intensity Cycle Ergometer Aerobic Exercise on 2-Min Walking Test Distance and Maximum Oxygen Uptake in Myasthenia Gravis Patients: A Randomized Controlled Trial

Fatigue and impaired functional capacity are more likely to be observed with myasthenia gravis (MG). MG prevalence in the Indonesian population is still limited. MG can benefit from participating in aerobic exercise without causing a decline in function, but relatively few exercise training studies have been conducted in this group of patients. This study analyzed how light-intensity cycle ergometer aerobic exercise influences functional and aerobic capacity in MG.

December 2023

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Child Neurology: Common Occurrence of Narcolepsy Type 1 and Myasthenia Gravis

Narcolepsy with cataplexy and myasthenia gravis are both chronic neurologic conditions causing symptoms of muscle weakness, often affecting facial muscles, and have both been attributed to an immune-mediated etiology. We report an adolescent girl diagnosed with both conditions and discuss possible shared mechanisms and the diagnostic challenges presented by her case to inform and aid clinicians managing children and young people with these rare conditions.

December 2024

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A Rare Case of Checkpoint Inhibitor-Induced Myasthenia Gravis

With rising interest in novel immunotherapies for cancer treatment, reporting on significant side effects becomes essential. There are few case reports on checkpoint inhibitor related Myasthenia Gravis. This case aims to provide knowledge on diagnostic and management strategies with patients that present with similar clinical findings to improve future patient care.

Nov 22, 2024

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Diagnostic and Dx Interpretations

Diagnosis

Myasthenia Gravis Foundation of America clinical classification (2)[C]:

History

The hallmark of MG is fatigability.

Physical Exam

Diagnostic Tests & Interpretation

Initial Tests (lab, imaging)

Test Interpretation

From 5-Minute Clinical Consult, 31st edition, by Frank J. Domino, MD, et al (2023)