Therapeutic potential of Glycyrrhiza glabra L. in managing oxidative stress-induced disorders

Abstract

Oxidative stress is a critical factor in the pathogenesis of various diseases, including cancers, neurodegenerative disorders, and inflammatory conditions. Glycyrrhiza glabra L., commonly known as licorice, has been utilized in traditional medicine systems for its therapeutic benefits, particularly its rejuvenating properties. This review provides a detailed examination of the ethnopharmacological applications, global distribution, and phytochemical composition of G. glabra. Furthermore, the key bioactive molecules of G. glabra, such as glycyrrhizin, glycyrrhizinic acid, and isoliquiritin, are highlighted for their roles in counteracting oxidative stress. These phytomolecules have been shown to exert significant effects through mechanisms such as modulation of antioxidant enzyme activities and inhibition of free radical production. Comprehensive literature searches were performed across major scientific databases, including PubMed, Web of Science, PMC, Google Scholar, Springer, ScienceDirect, and Research Gate, to synthesize information on G. glabra. The review explores how these phytomolecules contribute to the mitigation of oxidative stress-related disorders, including cancer, neurodegenerative diseases, and inflammatory conditions. By synthesizing data from experimental studies, this review underscores the therapeutic potential of G. glabra in managing oxidative stress-induced conditions. It also identifies gaps in the current understanding of its molecular mechanisms and suggests the need for further research, to enhance its application in therapeutic settings. Future studies shall focus on elucidating the synergistic effects of bioactive compounds of G. glabra and their integration into clinical practice and integrative research to fully exploit its medicinal benefits.