Summary
Typical MEI (MS at onset) and atypical MEI (GTCS at onset) were described in the present study. These 2 groups differed in form of onset, but there were no significant differences in clinical or EEG features.
Original Article
Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy
Medicine
Jiang, Yongning Ma; Zhou, Xiangqin MD, PhD
Abstract
Myoclonic epilepsy in infancy (MEI) is a rare syndrome characterized by generalized myoclonic seizures (MS) that occur within the first 3 years of life. In the present study, the form of onset, and clinical and electroencephalogram (EEG) features were analyzed. A retrospective chart review was conducted for 16 MEI patients between March 2009 and July 2022 in Peking Union Medical College. The clinical and video EEG (VEEG) characteristics, treatment strategy, and follow-up information were analyzed. Four cases presented with afebrile generalized tonic-clonic seizures (GTCS) at the onset of MEI (GTCS at onset or atypical MEI), while 12 cases presented with MS at onset (MS at onset or typical MEI). The 24-hour VEEG revealed a generalized discharge of polyspike (or spike)-and-wave complexes that lasted for 1–3 seconds in the ictal phase. All patients were treated with valproic acid monotherapy, and none of the patients experienced seizure recurrence. Furthermore, all patients had normal psychomotor development at the end of the follow up period. Typical MEI (MS at onset) and atypical MEI (GTCS at onset) were described in the present study. These 2 groups differed in form of onset, but there were no significant differences in clinical or EEG features.
Acknowledgments
We would like to thank the patients and their families for their participation in the study. We are equally grateful to the nursing and technical staff members of Peking Union Medical College for their hard work and dedication.
Author contributions
Yongning Jiang designed most of the investigation, data analysis and wrote the manuscript; Yongning Jiang and Xiangqin Zhou contributed to interpretation of the data and analyses. All of the authors have read and approved the manuscript.
