FcRn: A critical role in gMG1,2

What is FcRn?

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What is FcRn?

FcRn is present in several cell types, including vascular endothelial cells, and is responsible for recycling IgG antibodies. gMG is an autoimmune disorder of the musculoskeletal system caused by pathogenic IgG autoantibodies.1,3

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What role does IgG play in gMG?

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What role does IgG play in gMG?

In patients with gMG, pathogenic IgG autoantibodies target multiple components of the NMJ, including AChR, MuSK, and LRP4.4,5

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How does the FcRn pathway regulate IgG?

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How does the FcRn pathway regulate IgG?

FcRn has been found to recycle IgG, prolonging its half-life and maintaining high concentrations of the autoantibodies that attack the NMJ.1,2,5-8

Take a closer look

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What is FcRn?

Learn More

What is FcRn?

FcRn is present in several cell types, including vascular endothelial cells, and is responsible for recycling IgG antibodies. gMG is an autoimmune disorder of the musculoskeletal system caused by pathogenic IgG autoantibodies.1,3

Focus On FcRn

What role does IgG play in gMG?

Learn More

What role does IgG play in gMG?

In patients with gMG, pathogenic IgG autoantibodies target multiple components of the NMJ, including AChR, MuSK, and LRP4.4,5

Discover more about the role of IgG in gMG

See More

How does the FcRn pathway regulate IgG?

Learn More

How does the FcRn pathway regulate IgG?

FcRn has been found to recycle IgG, prolonging its half-life and maintaining high concentrations of the autoantibodies that attack the NMJ.1,2,5-8

Take a closer look

Watch Video

AChR=acetylcholine receptor • FcRn=neonatal Fc receptor • gMG=generalized myasthenia gravis • IgG=immunoglobulin G • LRP4=low-density lipoprotein receptor-related protein 4 • MuSK=muscle-specific tyrosine kinase • NMJ=neuromuscular junction

References: 1. Roopenian DC, Akilesh S. Nat Rev Immunol. 2007;7(9):715‐725. doi:10.1038/nri2155 2. Ward ES, Ober RJ. Trends Pharmacol Sci. 2018;39(10):892‐904. doi:10.1016/j.tips.2018.07.007 3. Gotterer L, Li Y. J Neurol Sci. 2016;369:294‐302. doi:10.1016/j.jns.2016.08.057 4. Gilhus NE. N Engl J Med. 2016;375(26):2570‐2581. doi:10.1056/NEJMra1602678 5. Behin A, Le Panse R. J Neuromuscul Dis. 2018;5(3):265‐277. doi:10.3233/JND‐170294 6. Ghetie V, Hubbard JG, Kim JK, Tsen MF, Lee Y, Ward ES. Eur J Immunol. 1996;26(3):690‐696. doi:10.1002/eji.1830260327 7. Ulrichts P, Guglietta A, Dreier T, et al. J Clin Invest. 2018;128(10):4372‐4386. doi:10.1172/JCI97911 8. Rødgaard A, Nielsen FC, Djurup R, Somnier F, Gammeltoft S. Clin Exp Immunol. 1987;67(1):82‐88.